Introduction: Diabetic foot is an important and devastating complication of the Type II diabetes mellitus. This study was mainly undertaken to study the combination of NPWT along with topical insulin application and its effect on wound healing when compared to NPWT alone. Material and Methods: A prospective interventional study was undertaken in the Department of Surgery, Bengaluru. A total of 100 patients were divided equally between the two groups where one group received NPWT alone and another group received NPWT with topical insulin. The wounds in both the experimental and control groups were opened on the 7th, 15th and 30th day and compared using the BATES - JENSEN WOUND ASSESSMENT TOOL. The details were collected by using a predesigned proforma and analysed using Statistical Package for Social Services (SPSS ver 20). Results: Majority of the patients in both experimental and control groups were aged more than 60 years and were males. There was no statistically significant difference between the NPWT alone and NPWT with topical insulin groups.