COVID-19 is a virus originated from Corona Virus which can severe acute respiratory syndrome (SARS) symptoms such as chest pain, dry cough, fever, and difficulty breathing. The AC and ventilation system is not only important for the thermal comfort occupants but to ensure the room is safe and free from infectious virus. Thermal comfort is important measurement in indoor space which influenced by temperature, Relative Humidity (RH), airflow velocity and others. This research was executed and focused on lecture room in Bilik Persatuan 10, Universiti Malaysia Perlis (UniMAP) instead of real hospital waiting room. It comes with the room dimensions 11.87m (Length) × 5.17m (Width) × 2.93m (Height) for the numerical study. In addition, Computational Fluid Dynamics (CFD) analysis is used to investigate the air flow pattern and temperature distribution inside the room. By using software Ansys FLUENT 19, field experimental and simulation work can be compared which have 14.55% difference in temperature distribution. It is expected by increasing the air velocity of the AC inlet diffuser influence the pattern of airflow in the room, but average temperature remains same for all these conditions.