The relationship between bladder cancer and alcohol consumption was investigated in a case-control study conducted in 506 patients (453 males and 53 females) with diagnoses of papillary urothelial carcinoma during 1978-1982 at "La Paz" hospital (Madrid), and an equal number of controls matched for age, sex and date of admission to the hospital. The results showed that the risk of bladder cancer does not increase with the intake of beer, wine and spirit beverages. However, a high risk of bladder cancer was associated with consumption of wine mixed with "gaseosa" (a refreshment beverage consisting of carbonated water plus artificial sweeteners).

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In order to learn about the influence of dietary factors and obesity on prostatic cancer in our environment, a case-control study was performed. The group of cases consisted of 90 men histologically diagnosed with prostatic cancer in the ‘La Paz’ hospital (Madrid) during the 4-year period of 1983–1987. The controls were 180 men selected to obtain a random sample of males from the same hospital, stratified according to age and date of admission as compared with the prostatic cancer patients. The results of the study revealed that a diet rich in animal fats as well as high in meat consumption increased the risk of prostatic cancer. Low ingestion of vitamin A or vitamin C and obesity were unassociated to the disease.

We describe a boy with testicular lymphangiectasis and Noonan's syndrome. Both testes showed seminiferous tubules with a reduced tubular diameter, containing few spermatogonia. The testicular interstitium exhibited a number of large, dilated lymphatic vessels forming irregular channels among the seminiferous tubules and surrounding them. Since there was no accompanying pathological condition to indicate an obstruction to the lymphatic flow at the level of the spermatic cord or in the regional lymph nodes, the abnormal development of testicular lymphatic vessels suggests a congenital malformation.

The formation of annulate lamellae (AL) has been studied in human Sertoli cells. Sertoli cells of infants did not show AL. Sertoli cells of 9-to 1 1-year-old boys showed incompletely circumferentially arranged cisternae of endoplasmic reticulum (ER), alternating with rows of vesicles, 200-300 nm in diameter, with a weakly osmiophilic content. The ER cisternae displayed both pores and attached ribosomes at a few sites. These membranous structures were also observed beside true concentrically arranged AL in pubertal Sertoli cells (11-13 years of age). Both types of membranous formations were continuous with parallel, rough endoplasmic reticulum cisternae (RER) that interconnected them. Adult Sertoli cells showed only AL, not the other peculiar membranous formation. These features suggest that the RER plus associated vesicles originate the AL in human Sertoli cells.