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A magnesium defieieney is known to be involved in the pathogenesis of primary hypertension. In patients with essential hypertension intima media thickness is increased in about 70% (ELSA Study), In our study, we investigated 21 patients ( 10 female, 11 male, average age 56.3 ± 6,6 years) with untreated essential hypertension (Grades I and II according to WHO guidelines). All patients had a hypomagnesemia in serum (1,57 ±0.11 mg%). In all patients we found a significant increase in intima media thickness of arteria carotis communis (0,97 ± 0,08 mm) (r =-0.869, p< 0.0001). The results show that a magnesium defieieney in' patients with essential hypertension may be of speeial pathogenetie importance. In addition, the role of magnesium deficiency in the development of arteriosclerosis has to be diseussed. Furthermore, we demonstrated a eonnection between magnesium defieieney and an inereased intima media thickness. In this context, calcium antagonist therapy or magnesium supplementation may be of' advantage when treating intima media thickness in hypertension.

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