No-till farming is farming technics that could better conserve the fertility of the farmland than till farming. Technically, it is greatly linked with the global sustainable agriculture framework. However, it needs to be economically sound for adoption by farmers. Scientific analysis of this aspect is rarely reported in the literature, accessible to the authors. This paper attempts to fill the gap by taking as a case study: the efficiency of tobacco Virginia farms in East Lombok (Indonesia), involving 15 no-till farming farmers and 15 till farming farmers as the sample. This sample was randomly selected from the population of Virginia farmers in purposively selected two villages in the research areas. Data collection was carried out during 2018 planting session using an individual structural interview technique. Farm efficiency was measured as Return to Cost (R/C) ratio. The significance of the efficiency difference between no-till and till farming was analyzed using a t-test. The analysis found that the R/C ratio of Virginia tobacco farms using no-till farming system (mean = 2.21) was significantly lower at 95% degree of confidence than the R/C ratio of virginal tobacco farms using till farming system (mean=3.47). In spite of this significant difference, the value of the R/C ratio was larger than one, indicating each of the systems was financially feasible. This explained the adoption of no-till farming by some of the Virginia tobacco farmers in the study areas. However, the wider adoption of the no-till farming system needed some improvements to reduce farm cost and increase revenue.