Carica papaya belonging to the Caricaceae family is an effective medicinal herb that is used as a folk medicine for the treatment of various diseases throughout the world. The present study was designed for evaluation of bioactive compound of dried papaya leaves extract received in supercritical fluid extraction method with special emphasis to the biochemical compound like phenol as well as the effect of various parameters like temperature, pressure, time and particle size on the phenol content. Maximunm phenol amount 1868.25 mg/100 gm was obtained at the at the 70°C and 250 bar pressure and minimum phenol 508.20 mg/100 gm was found at 70°C with 100 bar pressure in the supercritical fluid extraction method.

Papaya is most popular annual plant. Immediately after its harvesting, the highly perishable raw material, i.e. leaves, have to be preserved against deterioration and spoilage.  More often, during peak period, most of the crop is lost/wasted due to lack of proper post-harvest processing techniques. Drying is by far the most widely used treatment, which needs to be performed very carefully and preciously so as to preserve the bioactive compound of the leaves. Drying treatment and experimental tray drying method was carried out at the temperatures of 50°C, 60°C and 70°C to find and suggest the optimum drying condition for acquiring quality dried papaya leaves powder and bioactive compound like phenol, flavanoid and antioxidant activity of papaya leaves. Results have revealed that ‘total drying time’ is considerably reduced with the increase in drying air temperatures from 50°C to 70°C.  It could be recommended that the best drying temperature is 50°C of papaya leaves to retain the various bioactive compounds. Tray dryer at 50 0C for unblanched sample ensures the best results in quality and bioactive compound of papaya leaves Powder.