Alpha lipoic acid (ALA, thioctic acid), among other actions, is an essential coenzyme in the conversion of pyruvate to acetyl co-enzyme A. Therefore, it is necessary for the production of energy for aerobic organisms. Scientists have found that it can be used medically to help regenerate liver tissue, reverse the complications of diabetes mellitus, slow or stop the growth of cancer cells, and chelate heavy metals, among other actions. In this article, the authors describe the cellular mitochondrial damage from excessively high doses of this beneficial agent.

The equation of state of CS2 + CH2C12 has been studied over the whole composition range and for 298.15 < T/K < 319.15 and 0.1 < p/MPa < 40.0. The results indicate that the system shows a higher degree of nonideality than CS2 + CC14, as well as larger pressure dependences of GE, Vs, and TSE. While the Gubbins-Gray perturbation theory leads to conclusions in agreement with the data, the Deiters equation of state gives worse results than for CS2 + CC14.

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