The pituitary function is regulated by a complex system involving the hypothalamus and biological networks within the pituitary. Although the hormones secreted from the pituitary have been well studied, comprehensive analyses of the pituitary proteome are limited. Pituitary proteomics is a field of postgenomic research that is crucial to understand human health and pituitary diseases. In this context, we report here a systematic proteomic

Introduction:Asymptomatic bladder infection that is detected by a positive urine culture is also common among diabetes mellitus patient which progress to symptomatic infection and subsequent complication. Therefore it becomes essential to screen urinary tract infection in diabetes mellitus patient so that its progress to complication can be prevented. Hence present study has been designated to know the clinical, microbiological profile and antimicrobial sensitivity pattern of organism that causes UTI in diabetes mellitus patient. Material and methods: Based on exclusion and inclusion criteria 100 patients were included in this study, A detailed history of the patient were taken with respect to duration of diabetes and its symptoms complication, type and treatment. Regarding urinary tract infection, history was taken with respect to dysuria, burning, suprapubic pain; urgency, increased frequency and haematuria fever with chill rigor and vomiting suggestive of acute pylonephritis. Result: Out of 100 patients 36 patients have bacteriuria and 64 patients were without bacteriuria. Patient with HbA1C% above 10, who were suffering from UTI were 43, out of them 21 having bacteria in urine. The P value was 0.0642 and chisquare statistic was 5.496, which is not significant. Regarding relation between FPG and UTI, those patient whose FPG was less than 110mg/dl., five of them have UTI and four have bacteria in urine and one were without bacteriuria. Conclusion: bacteriuria was more common in female then male and patient above 50 year of age are more affected then younger one. Patient with type 2 diabetes mellitus and treated with oral hypoglycaemic agent are effected more frequently. Bacteriuria was more common in patient whose glycocylated haemoglobin was more than 10% and fasting plasma glucose was more than 200mg/dl. Patients having neuropathy are more prone to UTI. Most common organism isolate were E.Coli and were sensitive to cephalosporins and aminoglycosides.

The terminal hexosamines of bovine pituitary lutropin are thought to contain a sulfate moiety. In order to test this, a biosynthetic approach was adopted. When rat and buffalo (bovine) pituitaries were incubated with radioactive 35SOi -for 2 h in vitro it was observed that radioactivity gets incorporated into trichloroacetic acid-precipitable proteins. When the radioactive proteins were treated with an anti-sheep lutropin serum, radoactivity was found in the immunoprecipitate.The incorporation into rat lutropin like material was very marginal while it was very significant in the case of buffalo lutropin.

In the plastic industry for mold making, pocket milling is applied. The surface finish of the mold affects the quality of the plastic product, especially for toys. This can be achieved by minimising the surface roughness of the mold. To get a good quality product with a better production rate, the selection of the best combination of parameters in pocket milling is necessary. Multi-response optimisation can be applied for selecting such parameters which are suited for fulfilling the objective. In this study, one of the toy mold designs is selected as a pocket profile on which, two tool trajectories, viz Follow Periphery (FP) and Zigzag (ZZ), are applied for generation of pocket by varying Speed (S), Feed (F) and Step Over (SO). Box–Behnken Response Surface Methodology is applied to find the experimental runs. Two conflicting objectives minimising Surface Roughness (SR) and maximising Material Removal Rate (MRR) are obtained by applying Artificial Neural Networks (ANN) and Multi-Objective Genetic Algorithm (MOGA). Conformational experiments were conducted for the random set of Pareto results obtained from MOGA for both the tool trajectories to validate the model. From the analysis, it is observed that the FP tool path strategy is well suited to generate the pocket to get minimum SR and maximum MRR as the error percentage between the predicted and test results observed is 0.8085% for SR and 0.9236% for MRR.

BACKGROUND Health problems in tribal population are direct outcome of poverty, government policies that have adversely affected local livelihoods, high land alienations amongst tribals, threatened traditional agricultural practices, absence of forest rights and growing indebtedness. One study conducted by Yogesh Jain et al on tribes of central India indicated that in addition to infectious disease there is trend towards non-communicable diseases also. The aim of the study is to study the renal disease in relation to hypertension among tribal population of east Godavari District who is attending the OPD of General Medicine Department with pedal oedema.