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The response of the human vestibulo-ocular reflex system to a constant angular acceleration is calculated using a second order model with an adaptation term. After first reaching a maximum the peracceleratory response declines. When the stimulus duration is long the decay is mainly governed by the adaptation time constant T_a, which enables to reliably estimate this time constant. In the postacceleratory period of constant velocity there is a reversal in response. The magnitude and the time course of the per- and postacceleratory response are calculated for various values of the cupular time constant T₁, the adaptation time constant T_a, and the stimulus duration, thus enabling their influence to be assessed.

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A guinea pig model was used to study correlations between cis-platinum dosage and level of hearing loss, hair cell loss in the cochlea. Other parameters measured included weight loss and serum urea, creatinine, and cis-platinum levels. The damage to the inner ear expressed as hearing loss and hair cell loss demonstrated a highly positive correlation with the dosage of cis-platinum, and only a moderately positive correlation with the cis-platinum serum levels. Weight loss correlated well with hearing loss.