Objective. To determine the features of the influence of comorbid pathology on the outcome of metastatic gastric cancer in a patient of reproductive age. Materials and methods. A prospective analysis of a clinical case was carried out on the basis of the Department of Antitumor Drug Therapy № 1 of the Medical Center "Medical City", Tyumen. Results. The patients case, taking into account the data of instrumental examinations, objective examination, general condition of 40 % on the Karnofsky Scale, ECOG-3 (Eastern Cooperative Oncology Group), diagnosis, morphology and complications, was diagnosed as incurable; special methods of antitumor treatment were not indicated. In the current clinical situation, there was used the post-syndrome therapy, prolongation of antiretroviral therapy, examination for searching an infectious agent in the liquor and blood. Conclusions. Treatment of stage IV gastric cancer is aimed at prolonging the patient's life and improving its quality, stabilizing the disease; its goal is to achieve the same result in terms of quality of life and overall survival as in HIV-negative patients.

Tuberous sclerosis is one of the forms of monogenic hereditary pathology related to neurocutaneous diseases (phacomatoses). Diagnostic difficulties are associated with pronounced clinical polymorphism and age-dependent onset of symptoms. The article presents current data on the prevalence and clinical manifestations of tuberous sclerosis. A clinical case of tuberous sclerosis is given in several generations of the same family.

Prostate cancer metastases are a major cause of death among men. Almost all men who died from prostate cancer previously had metastases to the bones or other sites, including the lymph nodes, lung, and liver. Urethral metastases are one of the rarest locations of prostate cancer metastases. In this clinical case, we present a case of a man who had a recurrence of prostatic adenocarcinoma 36 months after radical prostatectomy; diagnosis and treatment of the patient are described.

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Retrospective analysis of foreign literature present in PubMed was carried out with the purpose to define possible influence of superinvasive opisthorchiasis on possible development of cholangiocellular carcinoma. After the research we conclude that O. Felineus doesn’t have an entry point during the initiation stage of carcinogenesis but rather acts as a promotor of cholangiocarcinoma (СС), and therefore cannot be considered a primary cause of the disease without additional influence of another carcinogens and specific factors that increase the probability of cholangiocarcinoma development (chronic inflammation, free radicals). Keywords: superinvasive opisthorchiasis, parasitism, immune system, carcinogenesis.