No abstract

Mg-Ca-TiO 2 composite scaffold loaded with different concentrations of doxycycline were prepared by space holder method. • Mg-based scaffold containing doxycycline possesses compressive strength of 5 MPa with porosities of 65%. • Antimicrobial activity of the composite scaffold increased with increasing doxycycline concentration. • Mg-based composite scaffolds containing low concentrations of doxycycline showed good biocompatibility. • These composite scaffolds showed good biological properties and desired drug release trend for bone infection treatment.