A simple, mild, and efficient oxidative copper-catalyzed regioselective trifluoromethylation of imidazo[1,5-a]-N-heteroarenes have been developed using Langlois , (NaSO 2 CF 3 ) reagent as CF 3 source. This method gives biologically relevant trifluorometh-ylated fused imidazoles in moderate to good yields with good functional group tolerance. The key features of the reaction are mild conditions, short reaction time, and room temperature reaction.

Herein, we report a mild and efficient hydroxymethylation of quinolines via an iron promoted cross-dehydrogenative coupling reaction under external acid free conditions.