Objective: Morphological assessment of the integration features of the combined use of porous permeable and textile mesh titanium nickelide with bone structures of the recipient zone. Methods: The study was carried out on 20 Chinchilla rabbits of both sexes at the age of 1-1.5 years with a bodyweight of 2500-4000 g. In animals, the artificial defect was created in one of the areas of the lower jaw, where a porous permeable titanium nickelide was installed, wrapped in a textile mesh version of it was installed. Animals were removed from the experiment for 30, 90, 180, and 360 days of research via intraperitoneal injection of mortal dose 1% solution thiopental sodium. The material for histological research was fixed in 10% buffered formalin during 12 hours after then washed with water and decalcified. The prepared sections were stained with hematoxylin-eosin. Microscopic examination of the stained preparations and photography were carried out using a light microscope Axioscope 40 (Zeiss, Germany) via a digital camera (Canon, Japan). Results: Studies have shown that with the combined use of porous permeable and textile mesh titanium nickelide, the artificially created defects of the mandibula between both contacting surfaces are formed directly, which leads to stable fixing. The porous structure of the material, its hysteresis behavior with organism tissues, provides widespread regeneration of cells and formed a homogeneous mature bone tissue bone tissue, both in the pores and around the structure. Conclusions: These and other facts indicate the high integration properties of the material that is investigated, which ensures optimal growth and population of osteogenic cells in the vicinity of defective bone areas in a growing organism. Keywords: Bone defect, osteointegration, regeneration, titanium nickelide, porous permeable implant.

Contrary to existing contraindication for cystectomy, we can conclude that extensive odontogenic cysts of jaw with involved of more than 2-3 intact teeth  and with loss of lower bone wall for more than1 cmisn’t the only sign for cystotomy. Application of correctly selected bone and plastic materials (in our case nickelid titanium granules in combination with PBRP) contributes to restoration of large-scale bone defects with formation of organotypical bone, corresponding to anatomy of the part, in optimal period of time which shortens the postsurgical rehabilitation period of patients and contributes to early functional loading to organ.

A special attention has been attracted by the method of endoprosthesis replacement of temporomandibular joint. This research is devoted to an increase of surgical treatment efficiency of temporomandibular joint bone ankylosis using porous titanium nickel endoprosthesises. The analysis of distant results of application of porous nickelid titanium endoprosthesises for replacement of mandibular condylar processes in patients with temporomandibular ankylosis affects, according to anatomical specifics of affected organ, allows to make conclusion on possibility of complete restoration of lost anatomical and functional specifics of dentomaxilla apparatus. Through correspondence of hysteresis behavior of lost organ and recipient tissues to hysteresis behavior of whole complex system of endoprosthesis, the connecting tissues from implant surrounding areas grow through porous structure of implant not causing any aggressive reactions from organism side.

Aim. To study the peculiarities of regeneration of fine-gauge reticulated titanium nickelide in near-defective tissues of the palate.Material and methods. The work was carried out on 10 female rabbits of the Shin Shila breed weighing 2,7-3,0 kg; an experimental investigation was carried out in the Central Research Laboratory of the Avicenna Tajik State Medical University. As the implantation material, we used a fine mesh titanium nickelide with a thickness of 40-50 microns threads and the size of 50x50 microns cells.Results and discussion. The morphological study revealed that after the surgery the mucous membrane covering the implant was edematous with foci of hyperemia and hemorrhages. Vessels were dilated and full-blooded, small and medium caliber vessels were constricted. In the zone of anastomosis, there were prevailing changes of inflammatory character with slight activation of local immunity. Fifteen days later the mucous membrane in the anastomosis zone partially recovered. Local immunity activation contributes to the restoration of normal structures in the implant area. Later it was noticed that as soon as blood supply to the implant zone was restored almost immediately from the areas bordering the operation zone the sprouting of the covering epithelium cells began.Conclusion. Regeneration processes in the artificially created defective areas of the palate, at the use of the titanium fine mesh nickelide begin on the border of the implant material contact with the tissues of the peri-defective zone at the expense of the local immune reactions activation with the following gradual transition to the other areas.