No abstract

a positive response. The probability of no response Summary to stress was analysed using logistic regression to We have investigated the cardiovascular and plasma obtain the probability of no response vs. end-tidal noradrenaline response to surgical incision under sesevoflurane concentration and the best-fit curve from voflurane anaesthesia and determined the end-tidal the maximum likelihood estimators of the model paraconcentration of sevoflurane that blocks the admeters. MAC BAR (mean±SE) was 8.0±0.2%, MAC BCR renergic response or responses to surgical incision was 7.9±0.2%. However, such high doses of se-(MAC BAR ) and changes in mean arterial pressure (MAP) voflurane cannot be used clinically because of their high toxicity. It may be preferable to combine sein response to surgical incision (MAC BCR ) in 50% of voflurane with other anaesthetics to reduce haemowomen. We randomly assigned 64 female patients, dynamic responses to strong stimulation. aged 20-49 years, to eight groups according to endtidal sevoflurane concentration: 5.0%, 5.5%, 6.0%,

A 70-year-old womanwith Cogan's syndrome first presented with central diabetes insipidus and then developed secondary hypothyroidism. Magnetic resonance imaging revealed a diffuse pituitary swelling without evidence of tumor. High-dose glucocorticoid therapy administered to treat Cogan's syndrome was very effective in suppressing the inflammatory process, and resulted in the reversal of the pituitary swelling and partial recovery of thyroid stimulating hormone secretion. This is the first case of hypopituitarism associated with Cogan's syndrome, a form of autoimmune vasculitis. The glucocorticoid-responsive pituitary lesion is best explained by autoimmune hypophysitis which shows pituitary swelling and is known to often associate with other autoimmunephenomena.