is chemically 1-cyclopropyl-7-((s,s)-2,8diazabicyclo(4.3.0)non-8-yl)-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid. Moxifloxacin is an antibiotic used to treat respiratory infections, including acute sinusitis, acute exacerbations of chronic bronchitis, and community-acquired pneumonia, as well as dermatological infections, as a second-line agent in tuberculosis. The literature survey [1-7] reveals that there is some HPLC methods have been reported. In this paper we describe a simple, inexpensive, sensitive and validated HPLC [8-12] method for the determination of Moxifloxacin HCl in bulk and pharmaceutical formulation.Working standard of Moxifloxacin HCl was obtained from well reputed research laboratories. HPLC grade Methanol, Merck grade Orthophosphoric acid and Triethylamine and Milli-Q water were procured from the market. The separation was carried out on isocratic HPLC system with pre-packed Luna C-18, 5µ (250 x 4.6) mm column using filtered and degassed mixture of Buffer: Methanol (55:45) as mobile phase. Buffer PreparationTransferred 2 ml of orthophosphoric acid into 1000 ml of water and the P H were adjusted to 2.5 with triethylamine, filtered through 0.45µm nylon membrane filter and degassed. Mobile phaseBuffer and methanol were mixed in the ratio of 55:45 and sonicated to degas.

No abstract

No abstract

Innovation development and standardization of Novel Herbal Formulation

No abstract