Ethyl-2-amino-4-chloro-6-(2, 4, 6 trichloro phenyl amino) pyrimidine-5-carboxylate and ethyl-2-amino 4-chloro-1, 3-dimethyl-6-(phenyl amino)-1,2,3,4 tetrahydro pyrimidine-5-carboxylate derivatives were synthesized through Cyclocondensation and Michel type of addition reaction with the aromatic anilines, guanidine and benzamidines. Synthesized novel derivatives were confirmed by elemental analysis viz., IR, 1HNMR and Mass spectroscopy.These novel derivatives have been screened for Antibacterial, Antifungal and Antiinflammatory activity.

Taste masking of bitter drugs has been challenge to scientists as taste is an important parameter governing patient compliance. Several oral pharmaceuticals, numerous food and beverage products and bulking agents have unpleasant bitter taste. In order to ensure patient compliance bitterness masking becomes essential. The desire of improving the palatability has prompted the development of numerous formulations with improved performance and acceptability. Several approaches namely sensory, barrier, chemical and complexation have been tried to mask the unpleasant taste of formulation. The purpose of the present was to evaluate the bitterness of the prepared syrup formulation by using human taste sensor.