One of the most promising trends in healthcare digitalisation is the personalisation and individualisation of therapy based on virtual representations of the human body through Human Digital Twins (HDTs). Despite the growing number of articles on HDTs, to-date no consensus on how to design such systems exists. A systematic literature review for designing HDTs used for behaviour-changing therapy and rehabilitation resulted in eight key design considerations across four themes: regulatory and ethical, transparency and trust, dynamism and flexibility, and behaviour and cognitive mechanisms.