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Unscheduled DNA synthesis, photoreplication repair capacity, and photoreactivating enzyme levels were examined in cells of individuals of a family with one case of XP and otherwise clinically normal parents. The patient's parents were first cousins. The activity of three paths of DNA repair was depressed in the XP cells. The clinically normal parents showed normal levels of unscheduled DNA synthesis as well as postreplication repair, however their photoreactivating enzyme level was as low as 30% of normal levels.

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(1) 5-HT levels were significantly increased during rat anaphylaxis in the blood, liver, pyloric stomach, small intestine and the skin. Although the activity of tryptophan-5-hydroxylase in the liver was also markedly increased, that of 5-hydroxytryptophan decarboxylase was raised only in the small intestine. MAO activity was increased in the liver, small intestine, pyloric stomach and lung. (2) 5-HT is probably one of the pharmacologically active mediators of rat anaphylaxis.