An experiment was conducted during Kharif 2012 and 2013 at Agricultural Research Station, Dhadesugur, University of Agricultural Sciences, Raichur, Karnataka, India, to evaluate the phytotoxicity and bio-efficacy of pyrazosulfuron ethyl 10 % WP (wettable Powder) @ 5, 10, 15 and 20 g a.i./ha against the weeds in transplanted rice. Sprays of Saathi (Market Sample) @ 15 g a.i./ha (gram active ingredient/hectare), Pretilachlor 50% EC @ 500 ml a. i/ha, hand weeding at 15 and 40 days after planting (weed free check) and a weedy check (untreated check) were also maintained. The dominant weeds were Echinochloacolona, Panicum repens, Cynodondoctylon, Ludwigiaparviflora, Leptochloachinensis and Cyperus sp. Application of pyrazosulfuron ethyl 10 % WP @ 20 g a.i./ha was recorded significantly higher grain yield (6266 kg/ha) by controlling the associated weeds in transplanted rice without any phytotoxic effect.