Coccidiosis is a serious parasitic disease that causes severe economic losses in rabbits. Commercial probiotics are widely used as potential therapeutic replacements for weight gain and increased resistance to many diseases. This study was conducted to determine the efficacy of a probiotic product called MiaClost as a liquid extract to protect animals from Eimeria stiedae infection. Thirty New Zealand white rabbits were divided into 5 equal groups. Rabbits in the first 3 groups were treated with concentrations of 10 7 , 10 8 , and 10 9 colony-forming units (CFU) per ml of MiaClost in their drinking water for 10 days before experimental infection with 1 × 10 4 of sporulated oocyst of E. stiedae. The last 2 groups served as positive and negative control groups. We found a significant reduction in mortality in rabbits receiving 10 9 CFU/ml MiaClost as well as an improvement in weight retention and food consumption ratios. Beneficial low oocyst output in feces of rabbits treated with 10 9 CFU/ml MiaClost led to a reduction in pathological changes in the liver and gall bladder. Our findings suggest that a liquid extract of MiaClost in concentration of 10 9 CFU/ml can provide protection against hepatic coccidiosis. Further research is needed to test this product against other diseases through different routes of consumption in animals.