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Tritiated 5\g=a\-androstane-3\g=a\,17\g=b\-diol(3\g=a\-diol) and 5\g=a\-androstane-3\g=b\,17\g=b\\x=req-\ diol (3\g=b\-diol)respectively were administered to patients with benign prostatic hypertrophy (bph) undergoing prostatectomy. In prostate and skeletal muscle homogenates and in plasma the total radioactivity content

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A method for the routine determination of plasma sex hormone-binding globulin (SHBG) binding capacity is introduced. In normal males an age dependent increase in SHBG binding capacity from 2.85 \ m=x\ 10\m=-\8 m in the age range 22\p=n-\44 years to 4.66 \m=x\ 10\m=-\8m in the age range 45\p=n-\64 years was found. A higher mean value of 6.41 \ m=x\ 10\m=-\8m was obtained in normal females, 20\p=n-\40 years old, and still higher values were found in females taking oral contraceptives. Although in male groups with benign prostatic hypertrophy or prostatic carcinoma the mean ages were somewhat higher than in the older normal group, a further age dependent increase in SHBG binding capacity in these diseases could not be demonstrated. In fact the mean values found were slightly although not significantly lower at 4.07 and 3.89 \m=x\ 10\ m=-\ 8 m, respectively. As expected, oestrogen treatment of males with prostatic carcinoma produced higher values.The importance of the binding of sex steroids, particularly the androgens, testosterone, and 5a-dihydrotestosterone (5a-DHT) to sex hormone-binding globulin (SHBG) in human plasma has been demonstrated in relation to uptake by target organs (Lasnitzki 8c Franklin 1975), influence on "free" steroid con¬ centrations (Rosenfield 1971;Vermeulen et al. 1969) and metabolic clearance Supported by the DFG, Sonderforschungsbereich 34 (Endocrinology).