IMPORTANCE Microvascular obstruction commonly affects patients with acute ST-segment elevation myocardial infarction (STEMI) and is associated with adverse outcomes. OBJECTIVE To determine whether a therapeutic strategy involving low-dose intracoronary fibrinolytic therapy with alteplase infused early after coronary reperfusion will reduce microvascular obstruction.

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This paper reviews the history of the development of computer methods for ECG interpretation. Selected highlights are presented which indicate how technological advances have paralleled the growth of the application of the technique to a point where globally over 100 million ECGs per annum are now interpreted by computer.