Aging is a natural, unavoidable physiological process of every human being. Aesthetic medicine, a rapidly growing on field of medicine, slows down this process. Autonomic mezotherapy is a specific type of needle mezotherapy using autologous platelets suspended in a small amount of plasma. Possibilities of use of blood preparations were discussed using 9 items of national literature and 5 foreign reports. The role of the plaques is not only a hemostatic function but also a function of cellular repair by the content of biologically active substances. The biostimulating effect consists in the activation of different cell types by growth factors. The technological change of the gel formulation creates new possibilities for the extension of aesthetic medicine.

Mesotherapy has been used in medicine since the 1950s and for aesthetic procedures since the 1970s. In the medical literature there are numerous reports about the positive effect of mesotherapy with regard to rejuvenating and improving the appearance of facial skin (reduction of fine wrinkles and discolouration, facial contour correction, improvement in skin tightness and elasticity). The variety of formulations used and the different techniques for administering them mean that the subjectively observed effects of mesotherapy cannot be objectively verified. To date, only a few studies have been published in the international literature where histopathological, ultrasound, and electron microscopy examinations were performed to confirm the efficacy of this method. Most studies, however, have been based on assessing subjective improvement. The aim of this paper was to review literature on the subject, namely 15 full-text reports on the effects of mesotherapy in the treatment of facial skin. The findings of the review show that the studies published to date are based primarily on subjective assessment methods, presenting the results of mesotherapy procedures through an analysis of "before and after" medical photographic documentation. It would seem necessary that further research should be conducted based on a unified protocol.