Precocious puberty is defined as the onset of menarche before 9 years of age, or the appearance of secondary sex characteristics before 8 years of age. It is associated with many psychosocial disturbances and adverse health outcomes such as: cardiovascular disease, shorter adult stature, an increased risk of type 2 diabetes and breast cancer. There is a general tendency to a progressive decrease in age of reaching puberty, specifically the onset of thelarche and menarche, girls being 10 times more affected than boys. This actual tendency can be explained by the increasing prevalence of childhood obesity and also by increasing environmental exposure to endocrine disruptor chemicals in household and personal care products.Phenols, phthalates, parabens and other compounds, such as polybrominated biphenyls and diethylstilbestrol are associated with precocious onset of puberty in girls, in case of in-utero or peripubertal exposure. These chemicals are frequently found in toothpaste, cosmetics, soups, shampoos, perfumes and other personal care products, interfering with sex hormones and puberty timing. This is why pregnant women should be more aware and avoid products based on these chemicals.

The chemical pregnancy is an early pregnancy loss occurring shortly after implantation. 50-75% of all miscarriages are considered to be chemical pregnancies. Although the pregnancy test is positive, the fetus cannot be detected on ultrasounds; it can be asymptomatic or it can have menstrual-like cramping and bleeding. There are numerous risk factors associated with miscarriage, such as: epidemiological, genetic, anatomical, endometrial, endocrine and immune factors, infections, inherited thrombophilia and antiphospholipid syndrome. Many drugs are related with spontaneous miscarriage, significant evidence being found for nonsteroidal anti-inflammatory drugs, inhaled corticosteroids, antidepressant medication, antiepileptic and antihypertensive drugs, the artemisinin-based combination therapy and for the diclofenac/misoprostol combination. Besides the common diseases like asthma, chronic hypertension, chronic kidney disease, thyroid disorders, diabetes mellitus, polycystic ovary syndrome and rheumatoid arthritis, there was also found a higher correlation with the risk of miscarriage for the Zika Virus infection. In conclusion, chemical pregnancy is a type of early pregnancy loss which usually doesn�t need prevention, associated with multiple risk factors.