In the present work aqueous fruit peel extract of Punica granatum was evaluated for its Anthelmintics activity against earthworm at three different concentrations (25, 50, 100 mg/ml). The Antihelmintic activity of extract was comparable with Marketed allopathic drugs (i.e. Piperazine citrate, Albendazole, Ivermectin, Levamisole- 25, 50, 100 mg/ml). 2% v/v Tween 80 in water was taken as a normal control. Marketed allopathic drugs concentrations were prepared using 2% v/v Tween 80. Antihelmintic activity was evaluated by considering the time required for mobility, paralysis and death of worms by the prepared extracts and marketed allopathic drugs concentrations. The data were found statistically significant by using one way ANOVA (P< 0.001).