One-pot reactions between carboxylic hydrazides and 2-isothiocyanatobenzonitrile afforded pharmacologically relevant 1,2,4-triazolo[1,5-c]quinazoline-5(6H)-thiones in good yields. These compounds were transformed into the corresponding

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Fused pyrimidine derivativesFused pyrimidine derivatives R 0515 Domino Cyclization of 2-Isothiocyanatobenzonitrile with Carboxylic Hydrazides -One-Pot Synthesis of 1,2,4-Triazolo[1,5-c]quinazoline-5(6H)-thiones. -A variety of thiones (III) are prepared from isothiocyanatobenzonitrile and hydrazides (17 examples) in the appropriate solvent in good to excellent yields. They are converted either directly or in two steps into amino-substituted derivatives. -(BLANK, J.; KANDT, M.; PFEIFFER*, W.-D.; HETZHEIM, A.; LANGER*, P.; Eur.