Objective: Community-based participatory research (CBPR) is based on power as fundamental to doing research. It evolved as a way of "knowing" from the broader idea of natural science. While previously viewed as objective, natural science is now understood as, at least, partially socially constructed. Method: History of research and epistemology is reviewed in terms of science. More specifically, we delve into science as social construction and how this conceptually opens the door to considering power in its processes. We then unpack CBPR as one way to do mental health research that artfully weaves power into method. Results: Natural science has evolved from believing scientism (i.e., the scientific method) is sufficient to describe physical and social phenomena to terms of social constructivism; namely, the social processes that impact investigators are necessary to understand science and its product. This highlights the role of power; namely, investigator choices about hypotheses, methods, analyses, and interpretations influence the products of individual studies. The recovery movement is the embodiment of power that significantly changed research and rehabilitation in mental health. CBPR has emerged to include people with lived experience in the research enterprise. CBPR is partnership among people with lived experience, health scientists, and service providers in all facets of doing research. Conclusions and Implications for Practice: Integrating CBPR into rehabilitation science has led to findings and actions that better serve community objectives. Continuing to weave CBPR into research and development will further enhance recovery in practice. Impact and ImplicationsThis review found community-based participatory research (CBPR) to be partnership between people with psychiatric disabilities and other stakeholders, including mental health scientists, family members, service providers, and administrators. CBPR is fundamentally action-based and grounded in power by enabling people to gather evidence so that they can make decisions about their communities.