Heterocyclic compounds containing N and S hetero atoms are useful material in drug research. Being a heterocyclic compound benzothiazole find use in research as a starting material for the synthesis of many bioactive structures. Several benzothiazole derivatives have been used against antiproliferative and DNA binding properties [1], anticancer and antioxidant activity against pancreatic cancer cell [2], antitumor and antiviral [3], antiinfective [4], human MCF-7cancer cell line [5], novel non-sulfamide NEDD8 activating enzyme inhibitors [6], antidepressant [7], hypoglycaemic and hypolipidemic [8], cervical cancer [9], anticonvulsant [10], anti-acetyl cholinesterase [11], kinase inhibitor [12], antituberculotic [13], antifungal [14], Candida albicans N-myristoyl transferase inhibition [15], antitumor [16], antimicrobial [17], diuretic activity [18], etc. Considering the importance of this nuclei, we have reported synthesis of some new benzothiazole derivatives by conventional method. All synthesized compounds were tested for their antifungal activity using standard drug. QSAR models first summarize a supposed relationship between chemical structures and biological activity in a data-set of chemicals. In order to select the best drug candidates for the next level of research,

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