Purpose To evaluate binding of P-selectin targeted microbubbles (MB) in tumor vasculature; a whole-body imaging and biodistribution study was performed in a tumor bearing mouse model. Methods Antibodies were radiolabeled with Tc-99m using the HYNIC method. Tc-99m labeled anti-P-selectin antibodies were avidin-bound to lipid-shelled, perfluorocarbon gas-filled MB and intravenously injected into mice bearing MDA-MB-231 breast tumors. Whole-body biodistribution was performed at 5 min (n=12) and 60 min (n=4) using a gamma counter. Tc-99m labeled IgG bound IgG-control-MB group (n=12 at 5 min; n=4 at 60 min), Tc-99 m-labeled IgG-control-Ab group (n=5 at 5 min; n=3 at 60 min) and Tc-99 m-labeled anti P-selectin-Ab group (n=5 at 5 min; n=3 at 60 min) were also evaluated. Planar gamma camera imaging was also performed at each time point. Results Targeted-MB retention in tumor (60 min: 1.8 ± 0.3% ID/g) was significantly greater (p=0.01) than targeted-MB levels in adjacent skeletal muscle at both time points (5 min: 0.7 ± .2% ID/g; 60 min: 0.2 ± 0.1% ID/g) while there was no significant difference (p=0.17) between muscle and tumor retention for the IgG-control-MB group at 5 min. Conclusions P-selectin targeted MBs were significantly higher in tumor tissue, as compared with adjacent skeletal tissue or tumor retention of IgG-control-MB.

Vitamin D plays a vital role in regulating calcium and phosphate metabolism and maintaining bone health. A state of prolonged or profound vitamin D deficiency (VDD) can result in rickets in children and osteomalacia in children and adults. Recent studies have demonstrated the pleiotropic action of vitamin D and identified its effects on multiple biological processes in addition to bone health. VDD is more prevalent in chronic childhood conditions such as long-standing systemic illnesses affecting the renal, liver, gastrointestinal, skin, neurologic and musculoskeletal systems. VDD superimposed on the underlying disease process and treatments that can adversely affect bone turnover can all add to the disease burden in these groups of children. The current review outlines the causes and mechanisms underlying poor bone health in certain groups of children and young people with chronic diseases with an emphasis on the proactive screening and treatment of VDD.

Introduction Alvin Toffler first used the term 'information overload' in his 1970 published book 'Future Shock'. Nearly 50 years later, facing work without spatial or temporal boundaries, this concept becomes reality. We conducted a systematic review on the determinants of information overload and on its consequences on health, quality of life, performance and quality of work. Methods We searched EBSCOhost (Academic Search Complete +BusinessSource Complete+PsycARTICLES+ PsycINFO+PSY-YNDEX), PubMed, and Web of Science (until March 2017) using a sensitive search string. Two independent reviewers screened the titles and abstracts for eligible articles and a third reviewer negotiated consensus. Further assessments of eligibility and quality assessment (of quantitative studies only) were conducted in a similar manner. The search resulted in 2535 records. The data of 33 full-text articles representing 16 quantitative and 18 qualitative studies were included and extracted. All quantitative studies were judged as of poor methodological quality: most studies applied a cross-sectional design and reported only univariate correlation coefficients. Due to the high heterogeneity of the studies, a meta-analysis could not be conducted.Results The results of our systematic review point to a relationship between high information amount and perceived information overload. According to the included studies, information overload was positively associated with work time spent with Emails, work-to-family conflicts and negatively associated -inter alia -with technical support, segmentation between work and family life, and appropriate Email management techniques. Discussion The most striking result was a clear lack of methodically sound studies on the determinants and consequences of information overload. Future studies on this important topic should provide a defined study base, should take the temporal sequence into account and should quantify information amount.

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Congenital abnormalities caused by human teratogenic drugs account for less than 1% of total congenital abnormalities. We report the first case of multiple anomalies associated with antenatal exposure to the anticancer agent Gefitinib. The patient conceived while she was on tablet Gefitinib 250 mg once a day for stage IV adenocarcinoma of lungs. The first scan done at 29 weeks 2 days showed liquor amnii on the upper limit of normal, single umbilical artery, left sided congenital diaphragmatic hernia, ventriculoseptal defect and left radial ray defect. The patient had a preterm delivery after one week and she refused autopsy. It is important to advise patients regarding contraception while undergoing chemotherapy as there is an increased risk of drug induced fetal malformations.