ID 22240 Poster Board 1Early life adversity in form of poor postnatal care is a major developmental stressor impacting behavior later in life. Previous studies have shown the impact of early life stress on behavioral and neural abnormalities. Specifically, research have demonstrated how early life stress in form of reduced bedding and nesting materials can result in sex-specific behavioral deficits and aberrations in the cerebellar regions of adult rodents. Little is known about how such alterations in cerebellar regions due to early developmental stress impact drug-seeking and reward mechanisms. To address this question, we assessed behavioral outcomes in adolescent C57/BL6 mice who were exposed to limited bedding and nesting materials at postnatal days 2-9. The animals were tested for a battery of behaviors including open field, novel object recognition, social preference, elevated plus maze, and morphine-induced conditioned place preference. There was a significant reduction in social preference in animals that underwent early-life stress compared to normally reared animals (t-test, p<0.05). Our results also indicated that animals undergoing post-partum adversity had increased preference towards the morphine-paired chamber in the morphine-induced conditioned place preference test (ttest, p<0.05). No differences were observed between the groups in novel object recognition or elevated plus maze. To identify cerebellar epigenetic markers that might underlie these behavioral deficits, we performed mRNA analysis of deep cerebellar nuclei and identified putative factors that might have a role in these behaviors. The current study aims to further understand how stressinduced neurodevelopmental changes can influence neuronal remodeling and affect addiction vulnerability in adolescents.

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Date Presented Accepted for AOTA INSPIRE 2021 but unable to be presented due to online event limitations. Engagement in prolonged sedentary behaviors negatively impacts health. Sedentary behavior and perceived occupational performance were explored among community-dwelling older adults. In this pretest–posttest study, a goal-based approach to OT was used for intervention. While additional research is needed, participant-developed goals involving meaningful occupations may impact occupational performance and sedentary behavior among community-dwelling older adults. Primary Author and Speaker: Allison Naber Additional Authors and Speakers: Whitney Lucas Molitor Contributing Authors: Michaela Dendinger, Vitoria Heier, Madison Michels, and Dana Vandenberg