Introduction: Depression is one of the psychiatric disorders and is the most common mood disorder. Stably and sometimes unstable, depression can involve and interfere with different aspects of life. By disrupting tasks, reducing motivation, causing anxiety, fear, and concern, depression impairs a significant part of the intellectual ability. Complications of depression have been proven on presence and absenteeism, accuracy in performing duties and efficiency. This study tends to determine the prevalence of depression among employees of Lorestan University of Medical Sciences and its relationship with demographic variables in 2017.Method: This cross-sectional study was conducted on employees of the Lorestan University of Medical Sciences in 2017. The subjects were 270 people who filled in adult BDI-II (including 21 3-point questions). The inventory is scored from 0 to 63(0- 13 minimal depression (normal)), 14-19 mild depression, 20-28 moderate depression, and 28-63 severe depression). Data were analyzed using SPSS version 23.Results: The mean depression score was 10.7; 48.1% had depression. Prevalence of depression was 12.6% mild depression, 11.1% moderate depression and 6.3% severe depression; 89 (33%) were single and 181 (67%) were married; Prevalence of depression was 29.47% in women and 30.28% in men.Discussion: Men were more likely to develop depression than women (27%), which is contrary to many reports. This study showed a significant relationship between age and prevalence of depression. There was a significant relationship between prevalence of depression and marital status; there was a significant relationship between workplace and the kind of work done by people and depression. There was a significant relationship between parental education and depression. There was no significant relationship between education and depression. However, some studies did not report this significant relationship.International Journal of Human and Health Sciences Vol. 03 No. 01 January’19. Page : 14-18