Targeted delivery combined with controlled drug release has a pivotal function in the future of personalized medicine. Target drug delivery system is one of the most considerable novel approach towards drug delivery system. Targated drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the ultimate tissues thus enhancing therapeutic index and bioavailability at site specific-delivery .Now a days various carrier systems which includes liposomes, niosomes, aquasomes,pharmacosomes, dendrimers, nanoparticles, microspheres, solid lipid nanoparticles, resealed erythrocytes etc. are utilized in target drug delivery system which provide site specific drug delivery. Drug targeting is the principle by which the distribution of drug in organism is maneuverer in manner such that its major fraction interacts exclusively with the target tissue at the cellular and subcellular. The present review deals with the Targeted drug delivery system its advantages, disadvantages, need of Targeted drug delivery system, Types, drug targeted to a specific organ such as Brain, kidney, heart, colon and respiratory tract and research update on Targeted drug delivery system. Various drug carriers which can be used in this advance delivery system are Niosomes, Liposomes, Nanoparticles, Monoclonal Antibodies.