In this paper, we describe the latest results involving molecular modeling and pharmacodynamic studies of the selected highly lipophilic compounds acting by human GABA transporter 1 (hGAT1) inhibition. The chemical interaction of 17 GABA analogues with a model of hGAT1 is described using the molecular docking method. The biological role of GAT1 is related to the regulation of GABA level in the central nervous system and GAT1 inhibition plays an important role in the control of seizure threshold. To confirm that GAT1 can be also a molecular target for drugs used to treat other neurological and psychiatric diseases (e.g., pain and anxiety), in the in vivo part of this study, potential antinociceptive and anxiolytic-like properties of tiagabine, a selective GAT1 inhibitor, are described.

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This study examines how the appearance of post-traumatic growth as a result of a traumatic event is affected by the extent to which the experiencing self dominates the narrating self (concepts introduced by Franz Stanzel). The experiencing self describes its feelings, needs, and desires, and reveals its own attitudes toward the situation and its circumstances. The narrating self aims to give a detailed account of the event, circumstances and its own actions, without saying much about its emotional state. Seventy-eight Polish women were asked to recount their traumatic experiences and answer questions about how the experience had affected their thinking about themselves and their world-view. The participants narratives were analyzed in terms of the dominance of either the experiencing self or the narrating self, or their possible balance. The participants also filled out questionnaires to measure post-traumatic growth and sense of purpose in life. The qualitative analysis suggested that greater post-traumatic growth was reported by women for whom the experiencing self either dominated in the narratives over the narrating self, or was balanced with the equally developed story of the narrating self. However, the quantitative analysis distinguished only between the experiencing self and narrating self positions, with the former demonstrating greater posttraumatic growth, whereas narratives that balanced both voices were intermediate in the comparison and were not distinguished from the other more pure positions. Taken as a whole, results support the inference that narration from an emotion-focused internal perspective facilitates personal growth in the face of very difficult life events.