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This study was performed to investigate the reactivity of 5alpha-cholestan-3-one (1) towards various chemical reagents to produce new steroidal heterocyclic derivatives. The aminothieno[2, 3:2, 3]cholestane derivative 2 was synthesized according to Gewald's conditions. The diazonium salt of compound 2 coupled with malononitrile to afford dicyanomethylenhydrazinothieno[2', 3':2, 3]cholestane derivative 5. The behavior of compound 5 towards nitrogen nucleophiles and several active methylene reagents was investigated. Additionally, a variety of steroidal heterocyclic derivatives like compounds 15a, b-22a, b were synthesized starting with 5alpha-cholestan-3-one (1). The structures of the compounds were established based on the analytical and spectral data. The in vitro antimicrobial activity of some newly synthesized compounds against bacteria and fungi was studied.

The present study aims to investigate physico‐chemical and bacterial characteristics of Nasser Lake water and houses drinking water, as well as fish cultures and its wastewater, in three villages west of Lake Nasser, Egypt. Fifteen representative water samples (Nasser Lake, different drinking water, fish cultures, and wastewater sources) were collected from three villages (Garf Hussein, Bashaier, and Kalabsha) in the west of Lake Nasser. Physico‐chemical, total viable counts, and bacterial qualification of water were achieved. The obtained results indicated that the produced water, supposed to be for domestic use in the three villages, contained all the tested organisms. The investigated water samples of the lake and drinking water in the selected three villages are supposed to be chemically safe according to World Health Organization and to Egyptian standards for drinking water. Water pollution index (WPI) was used in this study and the result concluded that for irrigation canals from the lake to the agriculture site, fish cultures (both concrete and earth pond systems), and drainage canal of fish ponds need to be treated before it is discharged to the lake. It is better to reuse it after treatment for agricultural purposes or recycled it to the fish cultures.