Noncoding RNA (ncRNA) includes short (miRNA) and long (lncRNA) that have important regulatory role in different biological processes. One of the important issue in which ncRNA involved is tumor induction and suppression. miRNA and lncRNA were vital players in many tumors including digestive system tumors. This study includes studying the role of 140 hsa-miR including miR-1 to miR-140 and their sponger lncRNA in esophageal and stomach cancers by 249 studies. The review revealed that each miR may play as oncogene only or tumor suppressor via upregulation and downregulation regulatory proteins in cell cycles and activation of physiological cascades. Some of miR have dual role in same type of tumor as oncogene and suppressive miR. Same thing is for lncRNA tacting as oncogenic via sponging some of miR when overexpressed to upregulate oncogenic protein or acting as suppression lncRNA when overexpressed to downregulate some oncogenic proteins activated by miR. The current review concludes the vital role of ncRNA (both miRNA and lncRNA) in some digestive system tumors as oncogene-promoting cancer viability, invasiveness, proliferation, and metastasis or as tumor suppressor inhibiting tumorigenicity or inducing apoptosis.

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Type two diabetes mellitus (T2DM) is the most common type of diabetes; it is characterized by hyperglycemia in the presence of hyperinsulinemia which is produced from beta cell insulin secretory malfunction and insulin resistance. This study was designed as a case-control study and was constructed to study the effect of type 2 diabetes mellitus on lipoprotein lipase and Apo lipoprotein C2 levels among lipid profiles in type 2 diabetes. The patient's ages ranged from (40-60) years. The serum sample of all groups was collected and used to measure the level of lipoprotein lipase and Apo lipoprotein C2 by using the ELISA method and to measure lipid profile by spectrophotometer technique. All samples were collected from Merjan Medical City at Babylon/ Hilla city. The study revealed that there was a significant decrease in the levels of lipoprotein lipase in patients with type 2 diabetes mellitus compared with the control group ( P < 0.001), also there was a significant increase in the levels of Apo lipoprotein C2 in the patient’s group compared with the control group ( P= 0.02).