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The multicomponent reaction between 2-naphthol, arylaldehydes and ammonia yields aminobenzylnaphthols in a process known as the Betti reaction, which was first uncovered at the beginning of the 20th century.

A simple and efficient synthesis of novel 6,6′‐(arylmethylene)bis(benzo[a]phenazin‐5‐ol) derivatives has been developed via a sequential one‐pot, two‐step, pseudo‐five‐component tandem reaction starting from 2‐hydroxynaphthalene‐1,4‐dione, o‐phenylenediamine, and aromatic aldehydes in the presence of 2‐aminopyridine as co‐catalyst and p‐TsOH as catalyst at 90°C under solvent‐free conditions. This sequential green process offers several advantages, such as operational simplicity, high yield, low cost, easy handling, clean reactions, absence of any tedious work‐up, and purification of products by non‐chromatographic methods.

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