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Background: Majoon Najah is a polyherbal traditional Unani formulation recommended for the treatment of neurological disorders. To evaluate antiepileptic and antidepressant activity of majoon najah and majoon najah extract in experimental animals. Methods: Anticonvulsant activity was tested using maximal electroshock induced convulsion in male sprague dawley rats using diazepam 3 mg/kg, p.o. as positive control. Pentylenetetrazole induced convulsion in swiss male albino mice was performed using phenytoin 25 mg/kg i.p. as positive control. The antidepressant activity of MN was evaluated using forced swim test model in male using Imipramine 20 mg/kg, p.o. as positive control. Results: Antiepileptic study data showed reduction of all parameters like, tonic hind limb extension, clonic convulsion and stupor; however the values were not found statistically significant at all tested dose levels. The results of forced swim test model indicated that majoon najah effectively showed significant (P<0.001) reduction in immobility duration in animals treated with majoon najah classical at dose 500 mg/kg bw and 1000 mg/kg bw as compared to control rats. Conclusion: Based on above findings, it may be concluded that majoon najah did not showed effectiveness in epilepsy however, the results evident that majoon najah is a potential Unani formulation having antidepressant activity which may be preferred as an alternative therapy over modern medicine to treat depression.

Rhazes (855-925 AD) the great scholar of Unani System Medicine (USM), initially classified Materia Medica according to animal, mineral and plant origin. Zahar Mohra is a Greenish white, good‑looking mineral stone with a slippery feel having a good smell and taste obtained from mines. In USM it is considered to be a universal antidote. The great Unani Scholar Yuhannā Māsawayh (777-857 AD), was one of the first physicians who mentioned the medicinal uses of Zahar Mohra. In Unani Medicine it is used to treat epidemic diseases such as Haiza (Cholera), Tawoon (Plague), as an antidote for different poisoning and to provide strength to vital organs. To check adulteration the quality standard of Zahar Mohra has been laid down. All the available information regarding this historically important stone has been compiled which will help the researcher to find a solution of pandemic disease in the current scenario. Key words: Zahar Mohra, Unani Medicine, Fade Zahar Kani, Mineral Bezoar