Background – Antibiotic resistance is rising to dangerously high levels worldwide. WHO’s new Global Antimi- crobial Surveillance System (GLASS) reveals widespread occurrence of Antibiotic resistance among 500000 people with suspected bacterial infections across 22 countries. India is no different from it, facing the problem of rising cases of multidrug-resistant TB which adds to the burden of infectious disease in India. Aim – In this literary review problem, current scenario, causes and solution on Antibiotic Resistance from an Ayurvedic perspective will be assessed. Methodology - Articles on Antibiotic Resistance from research papers, journals, and various sites and basic principles from Samhitas and various Ayurvedic Journals, Articles and Research papers on this perspective will be reviewed. Conclusion – Conclusion will be drawn after a thorough literature review on the above subject. Keywords- Antibiotic Resistance, Panchkarma, Rasayana