Summary: We describe a method for n.c.a. radioiodination of pyrrolidino tamoxifen (Idoxifene) based on the electrophilic destannylation of tributylstannyl pyrrolidino tamoxifen. The methods of separation using preparative tlc and HPLC give >95% radiochemical purity and > 7 0 % recovery.

Summary: A modified method for the synthesis of radioiodinated 4-125iodoantipyrine based on electrophilic iodination using Na103 as an oxidising agent is described. This straightforward method is reproducible and yields consistently high ( > 9 8 % ) radiolabelled 4 ' 2 5~~P .The use of solid phase extraction columns facilitates the removal of excess iodide and chloride ions with consistently high recovery ( > 8 0 % ) , simplifies the purification procedure, reduces preparation time and does not require the use of hplc technique.

No abstract