We report a case of non AF related Central retinal artery occlusion (CRAO) (Stroke) in untreated & uncontrolled hyperthyroidism. CRAO can be considered as an ocular analogue of stroke or an ocular equivalent of acute myocardial infarction. Generally hyperthyroidism is associated with Stroke (CRAO) because of atrial fibrillation. However, we report a case of uncontrolled hyperthyroidism with CRAO in the absence of atrial fibrillation. It is with an intent to highlight the fact that a hyperthyroid state is not only complicated by AF, but even hyperthyroidism in itself is a potential risk factor in the causation of stroke.We came across only one case report of ischaemic stroke in a hyperthyroid patient without AF. We could not find any case report of hyperthyroidism with AF related CRAO in literature. Hence we report first case of non AF related CRAO in hyperthyroidism & perhaps second case report of non AF related stroke in hyperthyroidism in literature so far. An uncontrolled hyperthyroid state is tantamount to a sustained inflammatory state that results in endothelial dysfunction by causing hypercoagulable state culminating in a small calibre vessel blockage.

Multiple sclerosis is a neurological disease, which affects young adults. Its course is unpredictable and runs over decades. It is considered as disease of unknown etiology in which there is demyelination of the brain and spinal cord. There is one case report of membranous GN in a case of progressive multiple sclerosis in the extant world literature. We report here perhaps the first case in the world of the occurrence of multiple sclerosis in a known case of chronic kidney disease with the presentation of acute optic neuritis, having a characteristics picture on MRI of multiple sclerosis in brain, abnormal VEP, oligoclonal bands in CSF and a prior episode of acute optic neuritis 3 years back. In our opinion, this case opens the flood gates for research & work to investigate whether the oxidative stress and the smouldering proinflammatory state in CKD can precipitate multiple sclerosis in a genetically predisposed host in a given environment. Multiple Sclerosis is often associated with a neurogenic bladder, but renal function is generally considered to be normal.

We report five cases of early or minimal change pancreatitis in our outpatient department. "Minimal Change Pancreatitis" is an entity that is very unfamiliar in majority of the practicing physician & surgeons. It is often called as "early chronic pancreatitis". All these terms are often used synonymously. It is a syndrome consisting of early phase of inflammation of pancreas which is manifested by less easily identifiable clinical features like chronic or recurrent abdominal pain syndrome with normal abdominal imaging studies e.g. USG

. We discuss the aspects of immune mediated poststreptococcal neuropsychiatric syndrome in adult.