Introduction and Objectives: Plantar fasciitis most common degenerative condition causes severe heel pain near the site of origin of the plantar fascia. Any heel pain due to plantar fasciitis persisting will often distress the patient, so right intervention at the right time is needed. Intra-lesional steroid is being used widely, but it has its own side effects. New studies have shown PRP promote removal of necrotic tissue but also enhance tissue regeneration and improve symptoms. We studied to assess the Functional outcome of autologous platelet rich plasma injection in patients with chronic plantar fasciitis. Objectives: To evaluate Functional outcome of autologous platelet rich plasma injection in patients with chronic plantar fasciitis. To recognize any complications associated with platelet rich plasma injection. Materials and Methods: A prospective study was done at Sri Siddhartha Medical College, Hospital & Research Center, from October 2015 to April 2017. Inclusion criteria include plantar heel pain longer than 6 weeks, failed conservative management of at least 4 weeks duration. In 100 patients, single dose of autologous PRP injection was given and followed up for 6 months. Patients assessed functionally using AOFAS, VAS scores and recorded before treatment and on follow-up at 1st month, 2nd month, 4th month, and 6th month. Results: We had highest number of patients in age group between 31 to 50 years. Out of 100 patients, 60 patients had 100% pain relieved, 28 patients had more than 50% pain relieved, 8 patients had less than 50% pain relieved and 4 patients had no pain relief. No other complications were seen in any patients. VAS and AOFAS score were statistically significant at follow ups (p value is <0.0001). Conclusion: PRP is a biological option for a common orthopaedic and recalcitrant orthopaedic problem like heel pain/plantar fasciitis. Our study has shown that autologous PRP injection is more effective treatment for long term relief of chronic heel pain.