Motor neuron disease (MND) is a devastating neurodegenerative disease with a poor prognosis and severe disability. Many potential external risk factors have been proposed as part of a gene-environment interaction in the etiology of MND. This result is also supported by current hypotheses concerning the cellular and genetic origins of MND. A motor neuronopathy that exacerbate frontotemporal dementia is known as MND (FTD). Frontal and temporal neocortical atrophy induce severe personality changes, inappropriate social conduct, and executive difficulties in people with FTD. Motor neuron disease causes symptoms such as bulbar palsy and limb amyotrophy. Frontal executive function deficits are seen in MND/amyotrophic lateral sclerosis (ALS) patients who are not considered demented. Furthermore, MRI has revealed anomalies in the frontal lobe. MND, according to Ayurveda, are caused by Vata Dosha. Vatais in charge of the nervous system's autonomic, peripheral, and central functions. It oversees the brain's cognitive and neurological processes. This article gives the information about the Ayurveda in management of MND, Panchakarma treatments for MND, various herbs and herbal formulations like Ashwagndha, Brahmi, Gotu kola, Shilajit, Kapakacchu, VrihatVatchintamani Ras, Medhyachurna used in the treatment and management of MND.

Motor neuron disease (MND) is a terrible neurodegenerative illness with a poor prognosis and significant impairment. Despite recent advances in symptomatic care, there are few medicines that can affect survival. However, a better understanding of the underlying etiology would substantially aid the task of finding effective treatments. In the etiology of MND, many potential external risk factors have been hypothesized as part of a gene-environment interaction. Following reports of a greater than predicted incidence of MND in professional athletes, there has been an increasing interest in the role of intensive physical exercise in the development of the disease. Current hypotheses about the cellular and genetic causes of MND also support this conclusion. Epidemiological evidence, on the other hand, is contradictory and inconclusive. FTD/motor neuron disease is the name given to a motor neuronopathy that complicates frontotemporal dementia (FTD) (MND). FTD is marked by severe personality changes, abnormal social behavior, and executive difficulties caused by frontal and temporal neocortical atrophy. Bulbar palsy and limb amyotrophy are symptoms of motor neuron disease. Micro vacuolation of the cerebral cortex is the most common histological alteration, along with atrophy of the bulbar neurons and anterior horn cells of the spinal cord. Large pyramidal cortical neurons, surviving cranial nerve nuclei, and anterior horn cells all have ubiquitinated inclusion bodies. Evidence is accumulating that some patients with classical MND/amyotrophic lateral sclerosis (ALS) who are not regarded to be demented show frontal executive function abnormalities. Moreover, frontal lobe abnormalities have been demonstrated by neuroimaging. Keywords: MND, FTD, ALS, motor neuron, behavior, physical activity, cognitive change.