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The present study examined some natural active compounds contained in the Libyan Arbutus pavarii Pampan. shrub that might be used as natural inhibitors of SARS-CoV-2, the responsible causative agent of coronavirus disease 2019 (COVID-19). A molecular docking method was employed to find out the capability of the selected molecules to interact with the virus main protease. Seven flavonoids from twenty-seven compounds belonging to different classes showed a remarkable ability to bind to the main protease of the novel coronavirus. The descending order of compounds with the highest binding affinity was as follows: Saponarin, Rutin, Delphinidin3-rutinoside, Neodiosmin, Kampferol-3-O-ß-D-rutinoside, Isoquercetin, and Hyperoside. The outcomes have provided a clear insight into the structure-activity relationship of Mpro targeting agents and may assist the future design of new drug candidates for the disease.

INTRODUCTION H. pylori was first discovered and isolated in 1983 by Warren and Marshall. H. pylori infection is well known to be the most common human infection worldwide (Go, 2002). H. pylorus is one of the most common causes of chronic bacterial infection in humans, directly related to peptic ulcer and gastric cancer (Yingzhi et al., 2002). The Center for Disease Control and Prevention (CDC) estimates that approximately two-thirds of the world's population harbors the bacterium, with infection rates much higher in developing countries than in developed nations (Sulakshana et al., 2015). In Egypt, The prevalence of H. pylori infection among patients greater than 6 years of age is 60% and rising to 90% by adulthood (Katherine and John, 2001).

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