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Introduction: Temporomandibular disorders (TMD) consist of numerous abnormalities that involve the TMJ, the masticatory muscles or both. Despite the uncertainty in understanding the underlying mechanism of TMD, it is quite clear that the onset and prognosis of TMD are closely related and influenced by the patient's stress level.Aim: To evaluate and report the impact of COVID-19 on the prevalence and severity of TMD symptoms in Cairo. Patients and methods:During the period from July 2020 to January 2021 a questionnaire was presented to patients with TMJ related complaints. This was done at the outpatient clinic of Faculty of Dentistry -Cairo University as well as patients treated at different private clinics across Cairo. The total number of questionnaires answered was 128. Results:The results showed a statistically significant increase in the number of patients with muscle symptoms in the group with positive COVID status when compared to those with a negative COVID status. (P value <0.001). Conclusion:From the data on hand, we conclude that the pandemic significantly impacted individuals in Cairo with TMD and it had a war-like effect as a global stressor event.