Introduction: The prostate is an accessory gland of the male reproductive system. It can be involved by a number of diseases ranging from inflammation to malignant diseases. Most common causes of prostatomegaly are benign prostatic hyperplasia, prostatitis, intraprostatic and periprostatic cyst, prostatic adenocarcinoma. Objectives: To evaluate the diagnostic usefulness of Transabdominal ultrasonography in enlarged prostate and compare the USG findings with the histopathological findings. Method: This cross sectional study was carried out in Radiology and Imaging Department of Sir Salimullah medical college and Mitford hospital, Dhaka, from January 2014 to December 2015 with clinically suspected enlarged prostate by department of Urology and referred to the Radiology and Imaging Department for proper evaluation whether benign or malignant by Trans-abdominal ultrasonography before treatment planning and further management. Results: In this study, mean age was 65. 8 years with standard deviation of mean ± 9. 7 years and the age ranged from 50 to 89 years. The most common symptoms associated with enlarged prostate were incomplete emptying 90%, frequency 84%, intermittency 80% urgency, 76%, weak stream, 70% straining 66%, nocturia 60%. Out of 50 patients, histopathological diagnosis of 44 (88%) was nodular hyperplasia, 2 (4%) was nodular hyperplasia with chronic prostatitis and rest of 4(8%) was adenocarcinoma of prostate. Conclusion: Ultrasonography is a non-invasive, available, radiation free procedure, which is used as a first line preliminary diagnostic procedure.