KEYWORDSThree different spectrophotometric methods are developed for the determination of naftidrofuryl oxalate (NAF) in pure form and its pharmaceutical preparation. The methods are based on charge transfer complexation reactions of NAF as n-electron donor with either p-chloranilic acid (PCA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) or tetracyano ethylene (TCNE) as π-receptors to give highly colored anion radicals species. The colored products were quantified spectrophotometrically at 515, 588 and 396 nm in PCA, DDQ and TCNE methods, respectively. Under the optimized experimental conditions, Beer's law is obeyed over the concentration ranges of 75.0-300.0, 25.0-150.0 and 15.0-50.0 μg/mL NAF for PCA, DDQ and TCNE methods, respectively. The proposed methods were applied successfully to the determination of NAF in pure form and its commercial tablets with good accuracy and precision. Statistical comparison of the results was performed using Student's t-test and Fratio at 95% confidence level, showing that there is no significant difference between the reference and the proposed methods with regard to accuracy and precision. Further, the validity of the proposed methods was confirmed by standard addition technique.Chloranilic acid Tetracyanoethylene Naftidrofuryl oxalate Pharmaceutical preparation Charge transfer complexation 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

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