Markhamialutea (Benth) K. Schum is an evergreen tree, commonly known as the Bell Bean Tree or Nile Tulip. It is widely distributed throughout tropical regions of Africa, Malawi, Tanzania, and Namibia.M. lutea uses in folk medicine and the different extracts of leaves, stems, barks , and roots possess various pharmacological activities. The purpose of this review is providing a complete and updated review on morphology, the active constituents of different parts of M. lutea such as sterols, triterpenoids, phenylpropanoid glycosides and flavonoids and their antioxidant, antiprotozoal, antiviral, antimicrobial effects and anticancer activities. Cycloartanetriterpenoids were predicted to possess anti-dementia activity using the Pass Online Web Resource.