Groundwater serves as the major source for drinking water and the only fresh water source in the dry season in Ca Mau province, the Vietnamese Mekong Delta. The study is performed to assess groundwater quality in the area. Groundwater Quality Index (GWQI), magnesium hazard (MH), sodium percentage (Na%), sodium adsorption ratio (SAR), permeability index (PI) combined with geostatistical tools were conducted by using groundwater quality data from 400 samples collected from private wells. GWQI values suggest that 7%, 63%, 28%, 2%, 1% of total samples are classified into excellent, good, poor, very poor and unsuitable for drinking water. High Cl and TDS are the main cause of high GWQI values suggesting that saltwater intrusion deteriorates groundwater quality. For irrigation purposes, 4%, 17%, 36%, 43% of total samples classify into Good, Permissible, Doubtful, Unsuitable respectively by Na% indicator; 55.0%, 30.9%, 11.9%, 2.2% of total samples is Excellent, Good, Doubtful and Unsuitable according to SAR, 54% samples are unsuitable by MH index, and all samples are good by PI. This study provides useful information on groundwater quality for various purposes in Ca Mau province, that could help water management and water users to identify the necessary approach for groundwater protection and water-treatment methods before utilising the groundwater source for specific purposes in the study area.