The undeclared chromium from Au/Pt dental alloy, or some other element might be responsible for the contact allergy thus far attributed to the gold.

Aim To investigate the diagnostic accuracy of O-(2-[ 18 F]-fluoroethyl)-L-tyrosine ( 18 F-FET) and fluoromethyl-( 18 F)-dimethyl-2-hydroxyethyl-ammonium chloride ( 18 F-FCH) computed tomography (CT) in patients with primary low-grade gliomas (LGG). Methods The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent both 18 F-FET and 18 F-FCH positron emission tomography (PET)-CT. Brain PET-CT was performed according to standard protocol – 20 minutes after intravenous injection of 185 MBq of 18 F-FET and 185 MBq of 18 F-FCH PET. Surgery and pathohistological diagnosis were performed in the next two weeks. Results We observed significantly better concordance between tumor histology and 18 F-FET PET (weighted Kappa 0.74) compared with both 18 F-FCH (weighted Kappa 0.15) and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18 F-FET (odds ratio 12.87; 95% confidence interval [CI], 0.49-333.70; P = 0.013, logistic regression analysis). Receiver operating characteristic curve analysis comparing 18 F-FCH (area under the curve [AUC] 0.625, 95% CI 0.298-0.884) and 18 F-FET (AUC 0.833, 95% CI 0.499-0.982) showed better diagnostic properties of 18 F-FET (AUC difference 0.208, 95% CI -0.145 to 0.562, P = 0.248). Conclusion Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18 F-FET seems to be more accurate than 18 F-FCH in the LGG diagnosis.

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