A B S T R A C TAs a result of the climate in which it is produced, as well as its recognizable taste and quality, the Šar cheese is a high demand product on the market of Kosovo and Metohija. The authors will, based on the research presented in this paper, give an overview of the production and the main carriers of the Šar cheese production. It will also present how Šar cheese production may be used in helping people survive in Sirinićka Župa. This paper would also, through direct surveys, observe perceptions and attitudes of the inhabitants of this region and provide practical guidelines on the production of the Šar cheese as development potential of the municipality of Štrpce, and recommend further agricultural reforms and tourist capacities of this region.

Будући да је концепт зелене економије релативно млад, недовољно је истражено да ли зелена економија може, и у којој мери, да буде фактор за постизање диференцираног положаја једне националне економије у односу на друге, као и каква је њена улога у постизању конкурентске предности те могућности за мерење конкурентске предности националне економије. Зато се у раду испитују и идентификују могућности зелене економије и развијају практичне смернице за искоришћавање потенцијала и мерење напретка у постизању конкурентске предности националне економије. Циљ рада је да се укаже на значај зелене економије као алата за мерење будуће конкурентности привреде и предузећа. Кључне речи: зелена економија, глобални индекс зелене економије, конкурентност националне еконoмије Abrstract: Since the concept of the green economy is relatively young, it is insufficiently investigated whether the green economy can be,and to what extent, a factor to achieve a differentiated position of a national economy in relation to others, and what is its role in achieving competitive advantage and the possibility of for measuring the competitive advantage of the national economy. Therefore, the paper examines and identifies opportunities of the green economy and develop practical guidelines for the utilization of resources and measure progress in achieving competitive advantages of the national economy. The aim is to highlight the importance of the green economy as a tool for measuring the future competitiveness of the economy and companies.

INTRODUCTION. Atrial fibrillation (AF) is the most common long-term arrhythmia and represents one of the main public health problems primarily due to the aging of the general population, in which this arrhythmia occurs more often and causes thromboembolic stroke. Cardioembolic stroke associated with AF is usually severe, highly recurrent, and often fatal or with permanent disability of specific stroke risk factors/modifiers. Common risk factors are summarized in a risk factor-based clinical score called the CHA2DS2-VASc Score. Poor INR control increases the risk of both thromboembolic and hemorrhagic complications, and the optimal balance between the benefits and risks of using oral VKAs is achieved when the TTR, or time in the therapeutic range, is ≥ 70% [9]. We present the case of a female patient that confirms the importance of oral anticoagulant therapy when the INR is in the therapeutic range between 2-3, in the largest number of measurements in the successful prevention of recurrent thromboembolic complications during a 14-year follow-up. CASE REPORT: We present a 60-year-old MD patient who first came to the Office of Internal Medicine "Dr. Bastać" in 2008 due to a feeling of instability and heart palpitations. Due to grade II hypertension, which is not well regulated, she has been taking antihypertensive therapy for the past two years, treats elevated cholesterol with statins, and states that in two years and a year before her first examination at the Office of Internal Medicine "Dr. Bastać", she had two minor strokes verified by MSCT of the endocranium. In our patient, a high CHA2DS2-VASc score of 4 was calculated (hypertension, female gender and previous stroke) and the estimated annual risk for stroke is 9.27% (TABLE 2). Her bleeding risk - HAS BLED Score is moderate and is 2 (hypertension, CVI). Based on CHA2DS2-VASc, the risk of adverse thromboembolic events is high and requires the introduction of oral anticoagulant therapy. The patient in therapy receives acenocoumarol according to the scheme so that the value of PT/INR is between 2.0 and 3.0. Good anticoagulation is defined as having 3 to 4 PT/INR values in the therapeutic range (similar to TTR 50 to 60% of the time), while poor anticoagulation is: 0-2 measured INR values in the therapeutic range (TTR <50%) [3]. In our patient, the TTR is about 70%, which represents excellent anticoagulation. During 14 years of monitoring for three months, as well as at the recent control on 04/29/2022. the patient feels well, with no new thromboembolic complications and no bleeding episodes. CONCLUSION. Antithrombotic therapy with vitamin K antagonists can achieve good anticoagulation and long-term successful prevention of repeated cardioembolic strokes in patients with atrial fibrillation. We emphasize the need for highly motivated patients to regularly monitor the level of anticoagulation via INR and the full engagement of the prescribing physician. In this case, we emphasize the frequent problem of delays in the introduction of anticoagulation therapy in atrial fibrillation. Stroke prevention is the cornerstone of care for patients with atrial fibrillation.

The causative agent of severe acute respiratory syndrome, corona virus 2 (SARS-CoV-2), the etiological agent of the COVID-19 disease, can infect the heart, vascular tissues and circulating cells via angiotensin-converting enzyme 2 (ACE-2), a cell receptor host for the viral spike protein. The focus of this review article is on the prevalence, risk factors, pathogenesis, clinical course and sequelae of myocardial damage caused by the disease COVID-19. Emphasis is also placed on the interactions of platelets with the vascular endothelium, which includes consideration of the role of the SARS-CoV-2 virus protein in triggering the development of generalized endothelitis, which further in a circle triggers more intense activation of platelets. Acute cardiac lesion is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. Clinical manifestations include direct cardiac damage and indirect immune response mechanisms that affect the cardiovascular (CV) system and have implications for the treatment of patients after recovery from acute COVID-19 infection. The most common direct cardiovascular lesion is an acute heart lesion, present in more than 12% of all infected patients and defined by a significant increase in cardiac troponins in the serum and echocardiographic signs of damage to the myocardial texture due to inflammation, impairment of segmental mobility or global systolic and diastolic function of the left ventricle and sometimes inflammation of the pericardium. Arrhythmias, venous thromboembolism and cardiomyopathy are predominant KV manifestations described in the patient with COVID-19. An analysis of 72,314 confirmed cases of COVID - 19 (Wuhan) showed total mortality of 1663 patients or 2.3%, with presence of a previous KV disease in 10.5%, diabetes Mellitus in 7.3% and arterial hypertension in 6%. Cardiovascular complications because of COVID-19 associated with comorbidities were: myocardial lesion (20 %), cardiac arrhythmias (16%), myocarditis and fulminant myocarditis with lowered ejection fraction (10%), non-occlusive myocardial infarction and venous thromboembolism and acute' cardiac insufficiency and cardiogenic shock. Hypertension and diabetes are the most frequent_comorbidities in those infected with COVID-19, for whom hospitalization was necessary. A Denmark study based on the national register of over 5000 patients with hospitalized COVID19 revealed that the risk from the acute myocardial infarction and ischemic stroke was 5 and even 10 times higher , respectively , during the first 14 days after COVID-19 infections in comparison with the period which preceded the known infection. Numerous individual cases point to extremely high values and troponin T dynamics typicalfor non-occlusive myocardial infarction with normal coronary arteries. Mechanisms of indirect cardiovascular lesions are: dysregulation of inflammatory or immune responses of hyperinflammation, vascular thrombosis and activation of platelets, autoimmune phenomena and adaptive immunological dysfunction in vascular thrombosis associated with COVID-19. Cardiovascular dysfunction and disease are often fatal complications of a severe COVID-19 virus infection. Cardiac complications can occur even canin patients without basic cardiac insufficiency, as a part of acute infections and they are associated with a more severe form of COVID 19 disease and increased mortality. Of COVID-19 patients treated in the intensive care unit 61% died because they had acute respiratory distress syndrome (ARDS), 44% of them had severe cardiac arrhythmias and 31% percent of them experienced a shock syndrome. Elevated troponin levels were rare in survivors of uncomplicated COVID19 (1%-20%), common in critically ill patients (46%-100%), and almost universally elevated in critically ill (ie, those requiring intensive care or mechanical ventilation) and those who did not survive. Some autopsy findings suggested myocardial infiltration by mononuclear leukocytes and revealed some cases of severe myocarditis with a dilated phenotype. Among patients hospitalized with COVID-19, evidence about acute damage of cardiac functions are frequent _ and include the following: acute cardiac insufficiency (3%-33%), cardiogenic shock ( 9%-17%), ischemia or myocardial infarction (0.9%-11%), left ventricular dysfunction (10%-41%), right ventricular dysfunction (33%-47%), biventricular dysfunction (3%-15%), stress cardiomyopathy (2%-5.6%), arrhythmias (9%-17%), venous thromboembolism (23%-27%) and arterial thrombosis as secondary viral mediated coagulopathy. COVID - 19 is associated with abnormalities of cardiac structures and functions including echocardiographic evidence of left ventricular dysfunction, regional wall movement abnormalities and mild reduction of right ventricular function. Involvement of myocardial lesion because of SARS - CoV -2infection was very much widespread even in patients with mild symptoms.

Due to favourable natural conditions, the inhabitants of the municipality of Štrpce were engaged in agriculture, livestock breeding and fruit growing for decades. Although to a lesser extent, interest in agriculture is still present today, with slight variations in the type of crops being grown. In recent years, there has been an expansion of raspberry growing and beekeeping, segments that have proven to be extremely profitable. The aim of this paper is to highlight the importance of agriculture in the overall sustainable economic development of the municipality of Štrpce and inhabitants individually. Based on the field research, the authors will suggest improvement of this industry, especially in the field of organic production. If the predictions are true, this will be crucial for the existence and well-being of people in this region.